This link will take you to the electronic medicines compendium (emc) website, which is a non-Novartis website.
Dr Vivek Misra assessment of frailty and CDK4/6i eligibility
Indication:
KISQALI® (ribociclib) is indicated for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor (AI) or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy (ET)
In pre- or perimenopausal women, the ET should be combined with a luteinising hormone-releasing hormone (LHRH) agonist
KISQALI is not recommended to be used in combination with tamoxifen.
For information on the safety profile of KISQALI in advanced breast cancer (aBC), click here.
Please consult your local Summary of Product Characteristics for the full KISQALI safety and tolerability profile.
Click the play button below to watch a video from Dr Vivek Misra
Join Dr Misra as he discusses approaches to assessing frailty in HR+/HER2– aBC and his clinical experience with treating these patients with CDK4/6is.
VIDEO
aBC, advanced breast cancer; AI, aromatase inhibitor; CDK4/6i, cyclin dependent kinase 4/6 inhibitor; ET, endocrine therapy; HER2–, human epidermal growth factor receptor 2-negative; HR+, hormone receptor-positive; LHRH, luteinising hormone-releasing hormone.
Reference
KISQALI® (ribociclib) Summary of Product Characteristics.
UK | October 2025 | FA-11527153
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Novartis online through the pharmacovigilance intake (PVI) tool at www.novartis.com/report, or alternatively email [email protected] or call 01276 698370.
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The Novartis portal for UK healthcare professionals (HCPs) and other relevant decision makers* is where you can find promotional information about Novartis products, therapy area materials and professional resources.
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Welcome to Pro.Novartis.com
The Novartis portal for UK healthcare professionals (HCPs) and other relevant decision makers* is where you can find promotional information about Novartis products, therapy area materials and professional resources.
*Other relevant decision makers particularly includes those with an NHS role who could influence in any way the administration, consumption, prescription, purchase, recommendation, sale, supply or use of any medicine but who are not health professionals.
This website is designed to be viewed on desktop.