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Yüksek kardiyovasküler (KV) riske sahip hastalarda inklisiran ile tamamlanmış ve devam eden 7 klinik çalışmadan elde edilen havuzlanmış post hoc analizde inklisirana uzun süreli maruziyetin, güvenlilik olaylarında artan bir insidansa yol açmadığı bulunmuştur.

Bu analiz aynı zamanda yüksek LDL-K seviyelerine sahip hastalarda, ASKVH, ASKVH risk eşdeğeri ve heterozigot ailesel hiperkolesterolemi ile birlikte, az sayıda homozigot ailesel hiperkolesterolemi hastalarında statinler ve/veya diğer oral lipid düşürücü tedaviler ile kombinasyon halinde yılda iki kez uygulanan inklisiran tedavisinin iyi tolere edildiğini gösteren en büyük veri setini sunmaktadır.

Sonuç olarak inklisiranın etkili ve tutarlı LDL-K düşürücü etkisi ile birlikte ele alındığında, veriler yüksek KV riski taşıyan hastalarda uzun süreli kullanımı için destek sağlamaktadır.

inklisiran33

*Open-label extension trials.

ADA= antidrug antibody; ASCVD= atherosclerotic cardiovascular disease; HeFH = heterozygous familial hypercholesterolemia; HoFH = homozygous familial hypercholesterolemia; MACE = major adverse cardiovascular event; PY = patient-years; TEAE = treatmentemergent adverse event; TESAE = treatment-emergent serious adverse event.

 

 

 

 

 

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