This page is intended for UK patients who have been prescribed remibrutinib for chronic spontaneous urticaria (CSU).1
The information on this website does not replace the Patient Information Leaflet which comes with your medication. Please always refer to your Patient Information Leaflet for more information. If you have any questions, ask your doctor or care team.
Rhapsido®▼ (remibrutinib)
What is remibrutinib?2,3
Remibrutinib is a medicine that can help to manage chronic (long-term) spontaneous urticaria (CSU) in adults whose symptoms are not controlled with antihistamine treatment.
Remibrutinib should not be used to treat any other forms of hives (urticaria)
Remibrutinib must not be used in children and adolescents under 18 years of age. It has not been studied in this age group
How does remibrutinib work?2,3
In CSU, certain immune cells in the body, called mast cells, become overactive.
Some of this is triggered by antibodies (proteins produced by the immune system) which attach to the outside of mast cells.
This signal is then relayed by proteins inside the cell, including Bruton's tyrosine kinase (BTK), leading to the release of substances like histamine, which cause itching, redness and swelling.
Remibrutinib is designed to help calm down this overactive immune response by blocking the action of BTK in those immune cells. By doing so, it aims to reduce or prevent the release of the substances that trigger CSU and swelling.
Treatment with remibrutinib aims to help with:
Reducing itching and hives associated with CSU
Reducing the number and severity of flare-ups
How should you take remibrutinib?1,2
Remibrutinib is taken as a 25 mg tablet, by mouth, twice a day, once in the morning and once in the evening.
Try to take remibrutinib at the same times each day to help you to build a routine
You can take remibrutinib with or without food
Remibrutinib tablets should be swallowed whole with water, and should not be split, crushed or chewed
Taking your tablets as prescribed is very important; this is called adherence
If you regularly skip doses or stop taking the tablets without consulting with your healthcare team, the medicine may not work as well and your symptoms could return
Taking remibrutinib as prescribed helps to keep a steady level of the medicine in your body, allowing it to help with controlling your hives and swelling
If you ever forget a dose, skip that dose and just take the next dose at the normal time; don’t take extra doses to make up for missed ones
If you take more remibrutinib than you should, talk to a doctor straight away
If you have any questions about how or when to take your medicine, your doctor, nurse or pharmacist can give you advice and help you find ways to fit it into your daily routine.
What can I expect during treatment with remibrutinib?1,2
Everyone’s experience is different, but here’s what you might expect while taking remibrutinib:
Symptom improvement
You may notice an improvement in your itch and hives but it may take several weeks to feel the full benefit
Monitoring
Your healthcare team may arrange appointments or blood tests from time to time. These help to make sure that the medicine is working for you
Possible side effects
Most people tolerate remibrutinib well; however, it can cause side effects in some individuals. Your healthcare team will explain what to look out for and what to do if you notice anything unusual
What are the possible side effects when taking remibrutinib?1,2
Very common: may affect more than 1 in 10 people:
Nose and throat infections (upper respiratory tract infections)
Common: may affect up to 1 in 10 people
Herpes virus infection
Headache
Bruising
Tiny red spots under the skin (petechiae)
Bruising under the skin (contusion)
A bleeding spot under the skin with a blue or purplish patch (ecchymosis)
Pink or brown urine/blood in the urine (haematuria)
Feeling sick (nausea)
Abdominal pain
Back pain
Fever (pyrexia)
Uncommon: may affect up to 1 in 100 people
Nosebleed (epistaxis)
Purple or red-brown spots on the skin (purpura)
A flat, bright red patch in the white of the eye (conjunctival bleeding)
Bleeding gums (gingival bleeding)
If you get side effects with any medication you are taking, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the information leaflet that comes in the pack.
Always tell your healthcare team about any new or worsening symptoms, even if they seem minor. This helps them make sure your treatment stays right for you.
What should I be aware of when taking remibrutinib?1,2
Other medicines
It is very important to tell your healthcare team and pharmacist about all the medicines you take or have recently taken, including prescription medicines, over-the-counter medicines, vitamins and herbal supplements. This is because some medicines can affect how remibrutinib works, and remibrutinib can affect how some other medicines work – in some cases, this could make your treatment less effective or increase the chance of side effects.
Pregnancy
Remibrutinib is not recommended during pregnancy. Animal studies have shown that this medicine may be harmful to an unborn baby, and although data in humans are limited, you should not take remibrutinib if you are pregnant. If you become pregnant while taking remibrutinib, stop taking it and contact your healthcare team as soon as possible.
You must use effective contraception throughout your treatment with remibrutinib and for at least 1 week after taking your last dose. Talk to your healthcare team or pharmacist if you are unsure which methods of contraception are suitable for you.
Breastfeeding
It is not known whether remibrutinib passes into breast milk and a risk to your baby cannot be ruled out. You should not breastfeed while taking remibrutinib, or for at least 1 week after your last dose. Talk to your healthcare team before making any changes to how you are feeding your baby, so that they can support you with this.
Talk to your healthcare team if you:
Think you may have an allergy to remibrutinib or other ingredients in this medicine
Have had a recent surgery or plan to have surgery. Your healthcare team may tell you to stop taking remibrutinib for 3–7 days before and after any planned medical or surgical procedures
Have bleeding problems or are taking a blood thinner medicine
Have liver problems
Have recently received or are scheduled to receive any vaccination. You should not receive live or live-attenuated vaccines during treatment with remibrutinib. Non-live vaccines can be given, but treatment interruption should be considered to optimise the immune response (from 1 week prior to vaccination until 2 weeks after)
Learn more about CSU
CSU, chronic spontaneous urticaria.
References
Rhapsido® (remibrutinib) Patient Information Leaflet.
Rhapsido® (remibrutinib) Summary of Product Characteristics.
Zuberbier T, et al. Allergy 2026;81(8):2582–2632.
UK | October 2026 | FA-11723597
Reporting side-effects
If you get side-effects with any medication you are taking, talk to your doctor, pharmacist or nurse. This includes any possible side-effects not listed in the information leaflet that comes in the pack. ▼ The medicine referred to in this material is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side-effects you may get. Please see www.mhra.gov.uk/yellowcard. for instructions on how to report side-effects.
